| CatalogCode: | NB110-57824 |
| ProductName: | XBP-1 Antibody |
| Product Description: | Rabbit Polyclonal anti-XBP-1 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide corresponding to 18 amino acids near the amino terminus of human XBP-1(Genbank accession No. BAB82982) |
| Specificity: | Reacts with human and mouse XBP-1. Recognizes the spliced and the non-spliced isoforms of XBP-1. |
| CrossReactivity: | Reacts in human and mouse. Not tested in other species. |
| Packaging: | 0.05 mg Affinity purified Rabbit antisera. |
| Uses: | Suitable for use in Western blot and immunocytochemistry. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded. |
| Control: | L1210 cell lysate |
| Background: | This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. The protein contains two domains commonly found in transcription factors that confer DNA binding and dimerization capability. This gene product was also separately identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. There is also a recent finding that the same agents that cause an ER stress response, the unfolded protein response, also increase transcription of this gene. This increase in transcription requires an ER stress response consensus binding element in the promoter. |
| Storage: | Store at 4 degrees C long term. |
| Purity: | Affinity purified |
| Host_Name: | Rabbit |
| Buffer: | PBS |
| ListPrice: | 325 |
| AppSummary: | WB, ICC |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-Tax responsive element binding protein 5 antibody, anti-TREB5 antibody, anti-X box binding protein 1 antibody, anti-XBP2 antibody |
| PackageSize: | 0.05 mg |
| GeneralRef: | The references listed below are for research purposes only. 1. Yoshida, H., et al., (2001), XBP1 mRNA is induced by ATF6 and spliced by IRE1p in response to ER stress to produce a highly active transcription factor, Cell, 107: 881-891. 2. Calfon, M., et al., (2002), IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA, Nature, 415: 92-96. 3. Haze, K., et al., (1999), Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic stress, Mol. Cell. Biol., 10: 3787-3799. 4. Little, E., et al., (1994), The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications, Crit. Rev. Eukaryot. Gene Expr., 4: 1-18. |
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