| Catalog Code: | NB110-57655 |
| Product Type: | Primary Antibody |
| Product Name: | Phospho-ZAP-70 (pY319) Antibody |
| List Price: | 325 |
| Clonality: | Monoclonal |
| Gene ID: | 7535 |
| Host: | Rabbit |
| Clone: | E227 |
| Isotype: | IgG |
| Product Description: | Rabbit Monoclonal anti-Phospho-ZAP-70 (pY319) (E227) [Tyr319] |
| Phosphorylated: | Tyr319 |
| Cross Reactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Species Summary: | Hu, Mu(-), Rt(-) |
| Background: | Zap-70, a Syk-family protein tyrosine kinase, plays a critical role in mediating T cell signal transduction in response to T cell receptor (TCR) activation (1). TCR-mediated activation of the Src-family kinases, Lck and Fyn, results in tyrosine phosphoryl |
| Alternate Names: | 70 kDa zeta associated protein antibody Selective T cell defect antibody SRK antibody STD antibody Syk related tyrosine kinase antibody Truncated ZAP kinase antibody Tyrosine protein kinase ZAP70 antibody TZK antibody ZAP-70 antibody Zeta chain associated |
| Specificity: | A synthetic phospho-peptide corresponding to residues surrounding Tyr319 of human ZAP-70 was used as immunogen. The antibody only detects ZAP-70 phosphorylated on Tyrosine 319. Predicted to cross-react with and bovine, based on sequence homology. |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Package Size: | .1 ml |
| Uses: | WB: 1:10,000IP: 1:20 |
| Application Summary: | IP, WB |
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