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| Catalog Code: | NB110-57643 |
| Product Name: | VEGFR1 Antibody |
| Product Description: | Rabbit Monoclonal anti-VEGFR1 (Y103) |
| Clone: | Y103 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Synthetic peptide corresponding to residues in N terminus of human VEGF Receptor 1 |
| Specificity: | A synthetic peptide corresponding to residues in N-terminus of human VEGFR1 was used as immunogen. The antibody can detect both VEGFR1 and its splice isoform sFlt1 |
| Cross Reactivity: | Reacts in human and mouse. Does not react in rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Background: | VEGFR-1 (vascular endothelial growth factor receptor 1) is a 180-kDa membrane receptor tyrosine kinase that is the receptor for vascular endothelial growth factor (VEGF), VEGFB and PGF. VEGF is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. VEGF has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders and other conditions (1). VEGFR-1 has seven extracellular Ig-like domains; the second domain from the N-terminus is necessary and sufficient for high affinity VEGF binding (2). The biological effects of VEGF are mediated by VEGFR-1 and VEGFR-2 (1), and two major tyrosine phosphorylation sites at Tyr 1213 and Tyr 1242 and two minor tyrosine phosphorylation sites at Tyr 1327 and Tyr 1333 exist in VEGFR-1 (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunohistochemistry 1:250, immunoprecipitation 1:100, Western Blot 1:10,000, Immunocytochemistry 1:250, |
| Species Summary: | Hu, Mu, Rt(-), |
| Alternate Names: | anti-Flt 1 antibody, anti-FLT antibody, anti-Flt1 antibody, anti-Fms like tyrosine kinase 1 antibody, anti-Fms related tyrosine kinase 1 antibody, anti-FRT antibody, anti-Tyrosine protein kinase FRT antibody, anti-Tyrosine protein kinase receptor FLT antibody, anti-Vascular endothelial growth factor receptor 1 Precursor antibody, anti-Vascular permeability factor receptor antibody, anti-VEGFR 1 antibody, anti-VEGFR1 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Ferrara, N. et al. The biology of VEGF and its receptors. Nat. Med. 9: 669-676 (2003). 2. Starovasnik, M.A., et al. Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states. J Mol Biol. 293: 531-44 (1999). 3. Ito, N., et al. Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules. J Biol Chem. 273: 23410-8 (1998). |
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