| CatalogCode: | NB110-57641 |
| ProductName: | VAV3 Antibody |
| Product Description: | Rabbit Monoclonal anti-VAV3 (EP1130Y) |
| Clone: | EP1130Y |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues near the C-term of human Vav3 was used as an immunogen. |
| CrossReactivity: | Reacts in human and mouse. Does not react in rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:100,000FC: 1:40IP: 1:50 |
| Background: | The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav) (1). Vav3 is expressed in most hematopoietic cells and non-hematopoietic tissues except ovary and skeletal muscles. T-cell stimulated and tyrosine phosphorylated Vav3 acts as an exchange factor for GTP-binding proteins RhoA, RhoG, and Rac1 (2). Also, tyrosine phosphorylated Vav3 mediates RTK signalizing, specifically IR, IGFR, and EGFR-mediated signaling pathways. Vav3 has been linked to as a factor for cell morphology modulation and an inducer for cell transformation (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, IP, WB |
| SpeciesSummary: | Hu, Mu, Rt(-) |
| ALTnames: | FLJ40431 antibody Protein vav 3 antibody Protein vav3 antibody VAV 3 antibody VAV 3 oncogene antibody VAV 3 protein antibody VAV3 oncogene antibody VAV3 protein antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Bustelo XR. Rev Oncog 7:65-88, 1996. 2. Bustelo XR. Mol Cell Biol 20:1461-1477, 2000. 3. Zeng L, et al. Mol Cell Bio 20:9212-9224, 2000. |
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