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| Catalog Code: | NB110-57639 |
| Product Name: | VAV Antibody |
| Product Description: | Rabbit Monoclonal anti-VAV (EP482Y) |
| Clone: | EP482Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues near the C-terminus of human Vav was used as an immunogen. |
| Cross Reactivity: | Reacts in human and rat. Does not react in mouse. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:2000ICC: 1:50IP: 1:50 |
| Background: | The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav) (1). First discovered based on its transforming properties, Vav is expressed mainly in hematopoietic cells and a few non-hematopoietic tissues, such as the pancreas and tooth enamels (2). As a signaling transducer, Vav is involved in T-cell activated transduction of T-cell antigen receptor (TCR). T-cell stimulated and tyrosine phosphorylated Vav acts as a catalyst in the exchange of guanosine nucleotides on Rac-1, a GTP binding protein (3). Using a mouse model, Vav expression has been determined to play an essential role in the cyctosketetal, proliferative, and apoptotic pathways for developing lymphoid cells and its signal response (2). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunoprecipitation, Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu(-), Rt, |
| Alternate Names: | anti-Vav 3 oncogene antibody, anti-Protein vav 2 antibody, anti-Protein vav 3 antibody, anti-Proto oncogene vav antibody, anti-VAV antibody, anti-Vav 1 oncogene antibody, anti-Vav 2 oncogene antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Bustelo XR. Rev Oncog 7:65-88, 1996. 2. Bustelo XR. Mol Cell Biol 20:1461-1477, 2000. 3. Turner M, et al. Immunity 7:451-460, 1997. |
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