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| Catalog Code: | NB110-57635 |
| Product Name: | TYK2 Antibody |
| Product Description: | Rabbit Monoclonal anti-TYK2 (EP1127Y) |
| Clone: | EP1127Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues near the C-terminus of human Tyk2 was used as an immunogen. |
| Cross Reactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:50,000IHC: 1:100 - 250ICC: 1:100 - 250IP: 1:50 |
| Background: | Novel non-receptor tyrosine-protein kinase, Tyk2, belongs to the tyrosine protein kinase family and plays a role in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Tyk2 is believed to phosphorylate the interferon-alpha/beta receptor alpha chain (1). It has been shown that Tyk2 links the interferon alpha/beta receptor to the cytoplasmic transcription factor that mediates activation of interferon-responsive genes (2). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunohistochemistry, immunoprecipitation, Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-JTK 1 antibody, anti-JTK1 antibody, anti-Non receptor tyrosine protein kinase 2 antibody, anti-Non receptor tyrosine protein kinase TYK2 antibody, anti-Protein Tyrosine Kinase 2 antibody, anti-TYK 2 antibody, anti-Tyrosine kinase 2 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Firmback-Kraft I, et al. Oncogene 5(9):1329-36, 1990. 2. Velazquez L, et al. Cell 70(2):313-22, 1992. |
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