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| Catalog Code: | NB110-57619 |
| Product Name: | TIRAP Antibody |
| Product Description: | Rabbit Monoclonal anti-TIRAP (EP1231Y) |
| Clone: | EP1231Y |
| Clonality: | Monoclonal |
| ListPrice: | 335 |
| Specificity: | A synthetic peptide corresponding to residues near the N-terminus of human TIRAP was used as an immunogen. This antibody detects 3 different isoforms of TIRAP. |
| Cross Reactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:1000IHC: 1:100 - 250 |
| Background: | Mammalian Toll-like receptors (TLRs) recognize conserved products of microbial metabolism and activate NF-kappa B and other signaling pathways through the adapter protein MyD88. All TLRs have a Toll/IL-1 receptor (TIR) domain, which is responsible for signal transduction. MyD88 is one such protein that contains a TIR domain. It acts as an adapter, being involved in TLR-2, TLR-4 and TLR-9 signaling. Toll-interleukin 1 receptor (TIR) domain-containing adapter protein (TIRAP) controls activation of MyD88-independent signaling pathways downstream of TLR4. Double-stranded RNA-binding protein kinase PKR is a component of both the TIRAP- and MyD88-dependent signaling pathways (1). It has been demonstrated that TRIF associates with TRAF6 and TBK1 independently, and activates two distinct transcription factors, NF- B and IFN regulatory factor-3, respectively (2). TIRAP is differentially involved in signaling by members of the TLR family and may account for specificity in the downstream signaling of individual TLRs (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunohistochemistry, Western Blot |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-Adapter protein wyatt antibody, anti-FLJ42305 antibody, anti-MAL antibody, anti-MyD88 adapter like protein antibody, anti-TIR domain containing adapter protein antibody, anti-Toll interleukin 1 receptor (TIR) domain containing adaptor protein antibody, anti-Toll interleukin 1 receptor domain containing adapter protein antibody, anti-Toll like receptor adaptor protein antibody, anti-Wyatt antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Horng T, et al. Nat Immunol, 2(9):835-41, 2001. 2. Sati S, et al. Immunology 171:4304-4310, 2003. 3. Horng T, et al. Nature. 420(6913):329-33, 2002. |
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