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| Catalog Code: | NB110-57599 |
| Product Name: | Stat-6 Antibody |
| Product Description: | Rabbit Monoclonal anti-Stat-6 (E265) |
| Clone: | E265 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues in C-terminus of human Stat-6 was used as immunogen. The antibody does not cross-react with other Stat family members. |
| Cross Reactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:5,000ICC: 1:250-500Flow Cytometry: 1:10IP: 1:30 |
| Background: | Janus family tyrosine kinases (Jaks) and signal transducers and activators of transcription (STATs) are involved in mediating gene expression in response to cytokines and interferons. Jaks associate with cytokine receptors; upon ligand binding, Jaks phosphorylate the receptor. The phosphorylated receptors are bound by SH2-containing proteins, one class of which is the STATs. Activated STATs, then, translocate to the nucleus to mediate gene transcription (1,2). Stat-6 is tyrosine phosphorylated in response to cellular interaction with IL-3 and IL-4 (3,4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis, immunoprecipitation, Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu(-), Rt(-), |
| Alternate Names: | anti-D12S1644 antibody, anti-IL 4 STAT antibody, anti-IL4 STAT antibody, anti-Interleukin 4 Induced antibody, anti-Interleukin 4 Induced Transcription Factor IL4 STAT antibody, Signal Transducer And Activator Of Transcription 6 antibody, anti-Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced antibody, anti-Signal Transducer And Activator Of Transcription 6 Nirs Variant 1 antibody, anti-STAT 6 antibody, anti-STAT interleukin4 induced antibody, anti-STAT6B antibody, anti-STAT6C antibody, anti-Transcription factor IL 4 STAT antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Leonard, W.J. and J.J. O'Shea. Jaks and STATs: biological implications. Annu. Rev. Immunol. 16: 293-332 (1998). 2. O'Shea, J.J., et al. Advances in the understanding of cytokine signal transduction: the role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency. J Clin Immunol. 17: 431-47 (1997). 3. Hou, J., et al. An interleukin-4-induced transcription factor: IL-4 Stat. Science 265: 1701-6 (1994). 4. Quelle, F.W., et al. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol. Cell. Biol. 15: 3336-3343 (1995). |
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