| CatalogCode: | NB110-57595 |
| ProductName: | STAT2 Antibody |
| Product Description: | Rabbit Monoclonal anti-STAT2 (Y141) |
| Clone: | Y141 |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues near N-terminus of human Stat-2 was used as immunogen. This antibody detects both long and short forms of Stat-2. |
| CrossReactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:500IHC: 1:100-250ICC: 1:50-100 |
| Background: | Stat-2 is a latent transcription factor that functions both as a signal transducer in the cytoplasm and an activator of transcription in the nucleus. Stat-2 is one of seven members of the Signal transducer and activators of transcription (Stats) family. Stat-2 is phosphorylated at Tyr690 by JAKs(1-3). Additionally, upon activation, Stat-2 will form a multiprotein DNA-binding complex with Stat-1 and ISGF3ăp48 (4). This activation subsequently allows the complex to translocate to the nucleus & bind specific enhancer elements. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | Homo sapiens interferon alpha induced transcriptional activator antibody interferon alpha induced transcriptional activator antibody MGC59816 antibody P113 antibody signal transducer and activator of transcription 2 113kD antibody STAT113 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Silvennoinen, O., Ihle, J. N., Schlessinger, J., and Levy, D. E. (1993) Nature 366, 583-585 2. Darnell, J. E., Jr. (1997) Science 277, 1630-1635 3. Fu, X.-Y., Kessler, D. S., Veals, S. A., Levy, D. E., and Darnell, J. E. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 8555-8559 4. Veals, S. A., Schindler, C., Leonard, D., Fu, X. Y., Aebersold, R., Darnell, J. E., and Levy, D. E. (1992) Mol. Cell. Biol. 12, 3315-3324 |
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