| CatalogCode: | NB110-57594 |
| ProductName: | STAT1 Antibody |
| Product Description: | Rabbit Monoclonal anti-STAT1 (Y93) |
| Clone: | Y93 |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues to the N-term of human Stat-1 was used as immunogen. This antibody will detect both alpha and beta isoforms. |
| CrossReactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:1,000IHC: 1:50-100 |
| Background: | Stat-1 is a latent transcription factor that functions both as a signal transducer in the cytoplasm and an activator of transcription in the nucleus. Stat-1 is one of seven members of the Signal transducer and activators of transcription (Stats) family (1). Stat-1 is activated by a different number of ligands; IFNá, IFNã, EGF, PDGF and IL6 (2-3). Upon tyrosine phosphorylation, Stat-1 dimerize with Stat-2 and associates with ISGF3/IR9 to form the ISGF3 complex (4). This activation subsequently allows the complex to translocate to the nucleus & bind specific enhancer elements. Additional complexes can form upon IFN stimulation. (1) |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | DKFZp686B04100 antibody ISGF 3 antibody Signal transducer and activator of transcription 1 91kDa antibody Signal transducer and activator of transcription 1 alpha/beta antibody Signal Transductor and Activator of Transcription 1 antibody STAT 1 antibody STAT 91 antibody STAT91 antibody Transcription factor ISGF 3 components p91 p84 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Darnell, J. E., Jr., Kerr, I. M., and Stark, G. R. (1994) Science 264,1415-1421 2. Shuai K, Horvath CM, Huang LH, Qureshi SA, Cowburn D, Darnell JE Jr. Cell. 1994 Mar 11;76(5):821-828. 3. Larner AC, David M, Feldman GM, Igarashi K, Hackett RH, Webb DS, Sweitzer SM, Petricoin EF 3rd, Finbloom DS. 1993 Sep 24;261(5129):1730-1733 4. Levy DE, Kessler DS, Pine R, Darnell JE Jr. Genes Dev. 1989 Sep;3(9):1362-1371. |
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