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| Catalog Code: | NB110-57590 |
| Product Name: | SOD1 Antibody |
| Product Description: | Rabbit Monoclonal anti-SOD1 (EP1727Y) |
| Clone: | EP1727Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues on human SOD1 was used as an immunogen. |
| Cross Reactivity: | Reacts in human and rat. Does not react in mouse. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:50,000IHC: 1:100 - 250ICC: 1:100 - 250FC: 1:40 |
| Background: | The eukaryotic copper,zinc superoxide dismutases are remarkably stable dimeric proteins that maintain an intrasubunit disulfide bond in the reducing environment of the cytosol and are active under a variety of stringent denaturing conditions. The structural interplay of conserved disulfide bond and metal-site occupancy in human copper,zinc superoxide dismutase (SOD1) is of increasing interest as these post-translational modifications are known to dramatically alter the catalytic chemistry, the subcellular localization, and the susceptibility of the protein to aggregation (1). Defective SOD is linked to motor neuron death and carries implications for understanding and possible treatment of the fatal neurodegenerative disorder familial amyotrophic lateral sclerosis (FALS). A crystal structure of human SOD, along with two other SOD structures, established that all 12 observed FALS mutant sites alter conserved interactions critical to the beta-barrel fold and dimer contact, rather than catalysis (2). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis, immunohistochemistry, Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu(-), Rt, |
| Alternate Names: | anti-ALS 1 antibody, anti-ALS antibody, anti-ALS1 antibody, anti-Amyotrophic lateral sclerosis 1 antibody, anti-Cu/Zn SOD antibody, anti-Cu/Zn superoxide dismutase antibody, anti-Homodimer antibody, anti-Indophenoloxidase A antibody, anti-IPOA antibody, anti-Mn superoxide dismutase antibody, anti-SOD 1 antibody, anti-SOD antibody, anti-SOD soluble antibody, anti-SOD1 antibody, anti-SOD2 antibody, anti-SODC antibody, anti-Superoxide dismutase 1 soluble antibody, anti-Superoxide dismutase Cu Zn antibody, anti-Superoxide dismutase cystolic antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Arnesano F, et al. J Biol Chem 279(46):47998-8003, 2004 2. Deng HX, et al. Science 261(5124):1047-51, 1993. |
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