| request information: |
|
| Catalog Code: | NB110-57586 |
| Product Name: | TMP21 Antibody |
| Product Description: | Rabbit Polyclonal anti-TMP21 |
| Clonality: | Polyclonal |
| ListPrice: | 285 |
| Concentration: | 0.9 mg/ml |
| Immunogen: | A synthetic peptide made to an internal sequence of the human TMP21 protein (within residues 100-200). [Swiss-Prot# P49755] |
| Cross Reactivity: | This antibody reacts with the human protein. No other species have been tested. |
| Packaging: | 0.1 ml peptide affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for Western blot analysis where a band is seen at ~21 kDa. |
| Localization: | Type I membrane. Golgi cisternae. |
| Background: | TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate gamma-secretase activity. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | peptide affinity purified |
| Host Name: | Rabbit |
| Buffer: | PBS + 30% glycerol |
| Application Summary: | Western Blot 2 ug/ml, Immunohistochemistry-Paraffin |
| Species Summary: | Hu |
| Alternate Names: | anti-Transmembrane emp24 domain-containing protein 10 antibody; anti-Transmembrane protein Tmp21 antibody; anti-21 kDa transmembrane trafficking protein antibody; anti-p24delta antibody; anti-S31I125 antibody; anti-Tmp-21-I antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.1% sodium azide |
| Homology: | 100% homology with human, monkey, mouse, rat, cow, hamster, and rabbit protein. |
order or
more information: | company product webpage |