| CatalogCode: | NB110-57583 |
| ProductName: | SMAD5 Antibody |
| Product Description: | Rabbit Monoclonal anti-SMAD5 (EP619Y) |
| Clone: | EP619Y |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues near the MH2 domain of human Smad 5 was used as immunogen. |
| CrossReactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:1,000ICC: 1:50Flow Cytometry: 1:30 |
| Background: | Smad 5 is a member of the Mothers Against Dpp (MAD)-related family of proteins. So far, eight Smads have been identified and can be divided into 3 subgroups based on their structure and function; pathway-restricted, common mediator and inhibitory. Smad 1, 5 and 8 serve as pathway-restricted Smads for the bone morphogenetic proteins (BMPs) signaling pathway (1). Smad 5 is directly activated by BMP type Ia or Ib receptors upon BMP-2 stimulation and transduced BMP-2 signals to the nucleus by forming a complex with Smad 4 (2-3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | DKFZp781C1895 antibody DKFZp781O1323 antibody Dwfc antibody hSmad 5 antibody hSmad5 antibody JV5 1 antibody MAD homolog 5 antibody MAD mothers against decapentaplegic homolog 5 antibody MADH 5 antibody MADH5 antibody Mothers against decapentaplegic homolog 5 antibody Mothers against DPP homolog 5 antibody SMA and MAD related protein 5 antibody SMAD 5 antibody SMAD family member 5 antibody SMAD mothers against DPP homolog 5 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Eppert et al. Cell 86: 543-552, 1996 2. Macías-Silva, M., Hoodless, P. A., Tang, S. J., Buchwald, M., and Wrana, J. L. (1998) J. Biol. Chem. 273, 25628-25636 3. Abdollah, S., Macías-Silva, M., Tsukazaki, T., Hayashi, H., Attisano, L., and Wrana, J. L. (1997) J. Biol. Chem. 272, 27678-27685 |
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