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| Catalog Code: | NB110-57577 |
| Product Name: | SMAD1 Antibody |
| Product Description: | Rabbit Monoclonal anti-SMAD1 (EP565Y) |
| Clone: | EP565Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues in human Smad1 was used as immunogen. |
| Cross Reactivity: | Reacts in human and mouse. Does not react in rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1: 500-2,000ICC: 1:100-250 |
| Background: | Smad 1 is a member of the Mothers Against Dpp (MAD)-related family of proteins. So far, eight Smads have been identified and can be divided in 3 subgroups based on their structure and function; pathway-restricted, common mediator and inhibitory. Smad 1, 5 and 8 serve as pathway-restricted Smads for the bone morphogenetic proteins (BMPs) signaling pathway (1). Smad 1 is involved in cell growth, apoptosis, morphogenesis, development and immune response (2). After phosphorylaion by the BMP type 1 receptor kinase Smad1 and co-Smad4 form a heteromeric complex and translocate to the nucleus to regulate transcription of target genes (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu, Rt(-), |
| Alternate Names: | anti-BSP 1 antibody, anti-BSP1 antibody, anti-Dwarfin A antibody, anti-DwfA antibody, anti-hSMAD 1 antibody, anti-hSMAD1 antibody, anti-JV 41 antibody, anti-JV4 1 antibody, anti-JV41 antibody, anti-MAD mothers against decapentaplegic homolog 1 antibody, anti-Mad related protein 1 antibody, anti-MADH 1 antibody, anti-MADH1 antibody, anti-Madr 1 antibody, anti-MADR1 antibody, anti-Mothers against decapentaplegic homolog 1 antibody, anti-Mothers against DPP homolog 1 antibody, anti-Sma and Mad related protein 1 antibody, anti-SMAD 1 antibody, anti-SMAD family member 1 antibody, anti-SMAD mothers against DPP homolog 1 Drosophila antibody, anti-Spinal muscular atrophy distal with upper limb predominance antibody, anti-TGF beta signaling protein 1 antibody, anti-Transforming growth factor beta signaling protein 1 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Wrana, J. L. 2000. Regulation of Smad activity. Cell 100:189-192. 2. Massague, J. 2000. How cells read TGF-beta signals. Nat. Rev. Mol. Cell Biol. 1:169-178. 3. Wrana et al. Nature 389:631-635. |
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