| CatalogCode: | | NB110-57571 |
| ProductName: | | SHP2 Antibody |
| Product Description: | | Rabbit Monoclonal anti-SHP2 (Y478) |
| Clone: | | Y478 |
| Clonality: | | Monoclonal |
| Specificity: | | A synthetic peptide corresponding to residues near the C-term of human SHP-2 was used as immunogen. This antibody is predicted to detect splice isoform 2 based on sequence analysis. |
| CrossReactivity: | | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | | 0.1 ml Rabbit ascites. |
| Uses: | | WB: 1: 5,000IHC: 1:50IP: 1: 50 |
| Background: | | SHP-2 (also called PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp and PTPN11) is a protein tyrosine phosphatase (PTP) expressed in most cell types (unlike SHP-1), (1). SHP-2 is involved in t the signal transduction stimulated by EGF, PDGF and Insulin. After cell stimulation, SHP-2 (as well as SHP-1), translocates from cytosol to the plasma membrane and binds to tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). When phosphorylated, SHP-2 has been shown to bind Grb2, EGFR, PDGFR, IRS-1 via its SH2 domain (3). Overexpression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome (4-5). |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.5% BSA. |
| ListPrice: | | 325 |
| AppSummary: | | IHC, IP, WB |
| SpeciesSummary: | | Hu, Mu(-), Rt(-) |
| ALTnames: | | BPTP 3 antibody BPTP3 antibody CFC antibody MGC14433 antibody Noonan syndrome 1 antibody Noonan syndrome 1 protein tyrosine phosphatase 2C antibody NS 1 antibody NS1 antibody Protein tyrosine phosphatase 2C antibody Protein Tyrosine Phosphatase Non receptor Type 11 antibody PTP 1D antibody PTP 2C antibody PTP1D antibody PTP2C antibody PTPN 11 antibody PTPN11 antibody SAP2 antibody SH PTP2 antibody SH PTP3 antibody SH2 domain containing protein tyrosine phosphatase 2 antibody SHIP2 antibody SHP 2 antibody SHPTP 2 antibody SHPTP2 antibody SHPTP3 antibody SIT protein precursor antibody Syp antibody Tyrosine protein phosphatase non receptor type 11 antibody |
| PackageSize: | | 0.1 ml |
| GeneralRef: | | 1. Ahmad, et al: Proc. Nat. Acad. Sci. 90: 2197-2201, 1993 2. Klingmüller, U., Lorentz, U., Cantley, L. C., Neel, B. G., and Lodish, H. F. (1995) Cell 80, 729-738 3. Xiao et al (1994) J. Biol. Chem. 269, 21244-212484. Chen, H. E., S. Chang, T. Trub, B. G. Neel. 1996. Mol. Cell. Biol. 16:3685 4. Tartaglia et al.Hum. Genet. 70: 1555-1563, 2002. 5. Tartaglia et al. Nature Genet. 34: 148-150, 2003. |
| more information: | | company product webpage |
|