| CatalogCode: | NB110-57570 |
| ProductName: | SHP-1 Antibody |
| Product Description: | Rabbit Monoclonal anti-SHP-1 (Y476) |
| Clone: | Y476 |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues in the C-term of human DHP-1 was used as immunogen. This antibody is predicted to detect isoforms 2 and 3 based on sequence analysis. |
| CrossReactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1: 1,000IHC: 1:50-100Flow Cytometry: 1:20IP: 1: 50 |
| Background: | SHP-1 (also called PTP1C, SH-PP1, HCP, SHP and PTPN6) is a protein tyrosine phosphatase (PTP) predominantly expressed in hematopoietic cells, and regulates multiple signaling pathways involved in hematopoietic cell growth, differentiation and activation (1). After cell stimulation, SHP-1 (as well as SHP-2), translocate from cytosol to plasma membrane and bind to the tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). SHP-1 has been involved in the negative regulation of various growth promoting receptors including receptor tyrosine kinase (c-Kit, CSF-1, EGF), cytokine receptors (IL-3, IFN-a/b) and other tyrosine based receptor CD22, B & T cell Ag receptor, Lck, Zap-70 and Vav (3-5). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.5% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, IHC, IP, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | 70 kda SHP 1L protein antibody 70 kda SHP1L protein antibody HCP antibody HCPH antibody Hematopoietic cell phosphatase antibody Hematopoietic cell protein-tyrosine phosphatase antibody HPTP 1C antibody HPTP1C antibody Protein tyrosine phosphatase 1C antibody Protein tyrosine phosphatase non receptor type 6 antibody Protein tyrosine phosphatase SHP 1 antibody Protein tyrosine phosphatase SHP1 antibody PTP 1C antibody PTP1C antibody PTPN 6 antibody PTPN6 antibody SH PTP 1 antibody SH PTP1 antibody SHP 1 antibody SHP 1L antibody SHP1L antibody SHPTP 1 antibody SHPTP1 antibody Tyrosine protein phosphatase non receptor type 6 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Banville, D.; Stocco, R.; Shen, S.-H. : Genomics 27: 165-173, 1995. 2. Klingmüller, U., Lorentz, U., Cantley, L. C., Neel, B. G., and Lodish, H. F. (1995) Cell 80, 729-738 3. Yi, T., J. Ihle. 1993. Mol. Cell. Biol. 13:3350. 4. Chen, H. E., S. Chang, T. Trub, B. G. Neel. 1996. Mol. Cell. Biol. 16:3685 5. Tomic, S., R. U. Greise, R. Lammers, A. Kharitonenkov, E. Imyanitov, A. Ullrich, F. Bohmer. 1995. J. Biol. Chem. 270:21277 |
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