| CatalogCode: | NB110-57476 |
| ProductName: | Alpha-Synuclein Antibody |
| Product Description: | Rabbit Monoclonal anti-Alpha-Synuclein (EP1536Y) [Ser129] |
| Clone: | EP1536Y |
| Clonality: | Monoclonal |
| Specificity: | A phosphor-specific peptide corresponding to residues surrounding Serine 129 of human Alpha-Synuclein was used as an immunogen. This antibody only detects alpha-synuclein phosphorylated on Ser129. |
| CrossReactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:5000 |
| Background: | Alpha-synuclein is expressed predominantly in brain, where it is concentrated in presynaptic nerve terminals (1). The deposition of the abundant presynaptic brain protein alpha-synuclein as fibrillary aggregates in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders. These disorders include Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, collectively referred to as synucleinopathies. Phosphorylation of alpha-synuclein at Ser 129 promoted fibril formation in vitro and these results highlight the importance of phosphorylation of filamentous proteins in the pathogenesis of neurodegenerative disorders (2). Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin. It is hypothesized that parkin and alpha-synculein interact functionally, namely, that parkin ubiquitinates alpha-synuclein normally and that this process is altered in autosomal recessive PD (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| ALTnames: | Alpha synuclein antibody MGC110988 antibody NACP antibody Non A beta component of AD amyloid antibody Non A4 component of amyloid precursor antibody PARK 1 antibody PARK 4 antibody PARK1 antibody PARK4 antibody Parkinson disease familial 1 antibody PD1 antibody SNCA antibody Synuclein alpha antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Jakes R, et al. FEBS Lett. 345(1):27-32, 1994. 2. Fujiwara H, et al. Nat Cell Biol 4(2):160-4, 2002. 3. Shimura H, et al. Science 293(5528):263-9, 2001. |
| Phosphorylated: | Ser129 |
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more information: | company product webpage |
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