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| Catalog Code: | NB110-57444 |
| Product Name: | Pyk2/FAK Antibody |
| Product Description: | Rabbit Monoclonal anti-Pyk2/FAK (E354) |
| Clone: | E354 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues in C-terminus of rat Pyk2 was used as immunogen. The antibody does not cross-react with other Fak family members. |
| Cross Reactivity: | Reacts in human and rat. Does not react in mouse. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:500IP: 1:50 |
| Background: | Proline rich protein tyrosine kinase (Pyk2) is a focal adhesion kinase (FAK2) related protein kinase protein also known as cell adhesion kinase ß (CAKß), related adhesion focal tyrosine kinase (RAFTK), or calcium-dependent PTK (CADTK) (3.4). Highly expressed in the nervous system, protein tyrosine kinase (Pyk2) is phosphorylated on the tyrosine residue by a variety of G-protein-coupled receptors & extracellular signals that increase the level of Ca+ intracellulary (1,2) |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunoprecipitation, Western Blot |
| Species Summary: | Hu, Mu(-), Rt, |
| Alternate Names: | anti-BBC 3 antibody, anti-BBC3 antibody, anti-BCL 2 binding component 3 antibody, anti-BCL2 binding component 3 antibody, anti-JFY 1 antibody, anti-JFY1 antibody, anti-p53 up regulated modulator of apoptosis antibody, anti-p53 Upregulated Modulator of Apoptosis antibody, anti-PUMA alpha antibody, anti-PUMA/JFY1 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Andreev J., Simon J.-P., Sabatini D.D., Kam J., Plowman G., Randazzo P.A., Schlessinger J.; Identification of a new Pyk2 target protein with Arf-GAP activity.; Mol. Cell. Biol. 19:2338-2350(1999). 2. Schlessinger J., 1995. Protein tyrosine kinase PYK2 involved in calcium-induced regulation of ion channel and MAP kinase functions. Nature376:737-745 3. Candice K. Klingbeil, Christof R. Hauck, Datsun A. Hsia, K.C. Jones, Shannon R. Reider and David D. Schlaepferaaaaaa Targeting Pyk2 to ß1-Integrin-containing Focal Contacts Rescues Fibronectin-stimulated Signaling and Haptotactic Motility Defects of Focal Adhesion Kinase-null Cells Journal of Cell Biology 152:97-110 (2001) 4. Avraham H., Park S.Y., Schinkmann K., Avraham S., 2000. RAFTK/Pyk2-mediated cellular signalling. Cell. Signal12:123-133 |
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