| CatalogCode: | NB110-57441 |
| ProductName: | PTEN Antibody |
| Product Description: | Rabbit Monoclonal anti-PTEN (Y184) |
| Clone: | Y184 |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues in the C-term of human PTEN was used as immunogen. |
| CrossReactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1: 500IHC: 1:50ICC: 1:50Flow Cytometry: 1:20IP: 1:50 |
| Background: | PTEN is a protein tyrosine phosphatase that acts as a tumor suppressor, as a lipid phosphatase that dephosphorylates the D3 position of phosphatidylinositol 3,4,5-trisphosphate and as an antagonist of the PI3k/AKT signaling pathway (1-3). PTEN structural domains includes an N-terminal phosphatase domain, a lipid binding C2 domain and a 50-amino acid C-terminal tail that contains a PD biding sequence (5). Phosporylation of the tail of the protein will suppress its activity and modify its conformation to a closed form an open form (5). Mutations in PTEN have been linked to glioblastoma, melanoma and prostate cancer. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, IHC, IP, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-Bannayan Zonana syndrome antibody anti-BZS antibody anti-ITGA 2 antibody anti-MGC11227 antibody anti-MHAM antibody anti-MMAC 1 antibody anti-MMAC1 antibody anti-Multiple hamartoma (Cowden syndrome) antibody anti-Mutated in Mutiple Advanced Cancers 1 antibody anti-Phosphatase and Tensin Homolog antibody anti-Phosphatidylinositol 345 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN antibody anti-Phosphatidylinositol 345 trisphosphate 3 phosphatase antibody anti-Platelet antigen BR antibody anti-PTEN 1 antibody anti-PTEN1 antibody anti-Tensin homolog antibody anti-TEP 1 antibody anti-TEP1 antibody anti-VLA 2 Receptor Alpha Subunit antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Vazquez, F., and Sellers, W. R. (2000) Biochim. Biophys. Acta 1470, M21-M35 2. Maehama, T., and Dixon, J. E. (1998) J. Biol. Chem. 273, 13375-13378 3. Maehama, T., Taylor, G. S., and Dixon, J. E. (2001) Annu. Rev. Biochem. 70, 247-279 4. Songyang, Z., Fanning, A. S., Fu, C., Xu, J., Marfatia, S. M., Chishti, A. H., Crompton, A., Chan, A. C., Anderson, J. M. & Cantley, L. C. (1997) Science 275, 73-77 5. Francisca Vazquez, Steven R. Grossman, Yuki Takahashi, Mihail V. Rokas, Noriaki Nakamura, and William R. Sellers, J. Biol. Chem., Vol. 276, Issue 52, 48627-48630, December 28, 2001 |
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