| CatalogCode: | NB110-57436 |
| ProductName: | PrP (Major Prion Protein) Antibody |
| Product Description: | Rabbit Monoclonal anti-PrP (Major Prion Protein) (EP1802Y) |
| Clone: | EP1802Y |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues near the C-terminus of human Prp was used as an immunogen. |
| CrossReactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:5000 - 10,000IHC: 1:100 - 250ICC: 1:100 - 250FC: 1:200 |
| Background: | Prion diseases are transmissible neurodegenerative disorders which affect a range of mammalian species. In humans they can be inherited and sporadic as well as acquired by exposure to human prions. Prions appear to be composed principally of a conformational isomer of host-encoded prion protein and propagate by recruitment of cellular prion protein (1). The function of the cellular prion protein (PrP) is still poorly understood. It has been proposed that one unprecedented role for PrP is against Bax-mediated neuronal apoptosis. It has been shown that PrP potently inhibits Bax-induced cell death in human primary neurons (2). An impaired synaptic inhibition may be involved in the epileptiform activity seen in Creutzfeldt-Jakob and other neurodegenerative diseases and it is believed that loss of function of PrP may contribute to the early synaptic loss and neuronal degeneration seen in these diseases (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, IHC, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Collinge J, Hum Mol Genet 6(10):1699-705, 1997 2. Bounhar Y, et al. J Biol Chem 276(42):39145-9, 2001 3. Collinge J, et al. Nature 370(6487):295-7, 1994. |
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