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| Catalog Code: | NB110-57435 |
| Product Name: | Presenilin 2 Antibody |
| Product Description: | Rabbit Monoclonal anti-Presenilin 2 (EP1515Y) |
| Clone: | EP1515Y |
| Clonality: | Monoclonal |
| ListPrice: | 335 |
| Specificity: | A synthetic peptide corresponding to residues on the C-terminus of human Presenilin 2 was used as an immunogen. |
| Cross Reactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:200,000IHC: 1:50 - 100ICC: 1:100 - 250IP: 1:50 |
| Background: | Presenilin (PS) facilitates gamma-secretase cleavage of the beta-amyloid precursor protein and the intramembraneous cleavage of Notch1 (1). Presenilin (PS) is essential for the gamma-cleavage required for the generation of the C terminus of amyloid beta-protein (Abeta). The discovery that a deficiency of presenilin 1 (PS1) decreases the production of amyloid beta-protein (Abeta) identified the presenilins as important mediators of the gamma-secretase cleavage of beta-amyloid precursor protein (APP). It has been shown that two conserved transmembrane (TM) aspartates in PS1 are critical for Abeta production, providing evidence that PS either functions as a required diaspartyl cofactor for gamma-secretase or is itself gamma-secretase. Presenilin 2 (PS2) shares substantial sequence and possibly functional homology with PS1. Here, we show that the two TM aspartates in PS2 are also critical for gamma-secretase activity, providing further evidence that PS2 is functionally homologous to PS1 (2). PS are found primarily within intracellular membranes, including the endoplasmic reticulum (ER) and the trans-Golgi network as well as the plasma membrane. PS are also expressed in most cell types throughout development (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunohistochemistry, immunoprecipitation, Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-AD 3L antibody, anti-AD 3LP antibody, anti-AD 4 antibody, anti-AD 5 antibody, anti-AD3L antibody, anti-AD3LP antibody, anti-AD4 antibody, anti-AD5 antibody, anti-Alzheimer disease 4 antibody, anti-Alzheimer disease familial type 4 antibody, anti-E5 1 antibody, anti-EC 3.4.23. antibody, anti-Presenilin2 antibody, anti-PS 2 antibody, anti-PS2 antibody, anti-PSEN 2 antibody, anti-PSNL 2 antibody, antiPSNL2 antibody, anti-STM 2 antibody, anti-STM2 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Steiner H, et al. J Biol Chem. 274(40):28669-73, 1999. 2. Kimberly WT, et al. J Biol Chem 275(5):3173-8, 2000. 3. Kopan et al. Gene Dev. 14(22):2799-2806, 2000. |
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