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| Catalog Code: | NB110-57433 |
| Product Name: | Calcineurin A Antibody |
| Product Description: | Rabbit Monoclonal anti-Calcineurin A (EP1669Y) |
| Clone: | EP1669Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues on the N-terminus of human PP2B was used as an immunogen. |
| Cross Reactivity: | Reacts in human, mouse, hamster and rat. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | This antibody may be used for wstern blot, immunohistochemistry and immunoprecipitation. |
| Background: | The calcium- and calmodulin-dependent protein phosphatase calcineurin (PP2B) has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fiber gene expression in skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation (1). The Z-disc is a highly specialized multiprotein complex of striated muscles that serves as the interface of the sarcomere and the cytoskeleton. Calsarcins represent a novel family of sarcomeric proteins that serve as focal points for the interactions of an array of proteins involved in Z-disc structure and signal transduction in striated muscle (2). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis 1:100, immunoprecipitation 1:100, Western Blot 1:10000, |
| Species Summary: | Ha, Hu, Mu, Rt, |
| Alternate Names: | anti-Calcineurin A alpha antibody, anti-CalcineurinA antibody, anti-Calmodulin dependent calcineurin A subunit alpha isoform antibody, anti-CALN antibody, anti-CALNA 1 antibody, anti-CALNA antibody, anti-CALNA1 antibody, anti-CAM PRP catalytic subunit antibody, anti-CCN 1 antibody,anti-CCN1 antibody, anti-CNA 1 antibody, anti-CNA antibody, anti-CNA1 antibody, anti-PPP2B antibody, anti-PPP3CA antibody, anti-Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform antibody, # Serine/threonine protein phosphatase 2B catalytic subunit alpha isoform antibody, anti-PP2B antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Frey N, et al. Proc Natl Acad Sci 97(26):14632-7, 2000 2. Frey N, et al. J Biol Chem 277(16):13998-4004, 2002 |
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