| CatalogCode: | | NB110-57431 |
| ProductName: | | PP2A Antibody |
| Product Description: | | Rabbit Monoclonal anti-PP2A (YE351) |
| Clone: | | YE351 |
| Clonality: | | Monoclonal |
| Specificity: | | A synthetic peptide corresponding to residues in N-terminus of human PP2A-alpha was used as immunogen. Predicted to cross-react with bovin and pig, based on sequence homology. |
| CrossReactivity: | | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | | 0.1 ml Rabbit ascites. |
| Uses: | | WB: 1:500IHC: 1:50-100 |
| Background: | | Protein phosphatase type 2A (PP2A) is a protein serine/threonine phosphatase that controls fundamental cellular processes, including transcription, translation, metabolism, cell growth, apoptosis, and varied other signal transduction pathways (1-3). PP2A is comprised of a core enzyme, which is made up of catalytic C and regulatory A (PR65) subunits, and a secondary regulatory B subunit. This B subunit contains four different protein families. In response to EGF or insulin, it has been shown that Src phosphorylates PP2A at Tyr307, thereby inactivating PP2A (4). |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | | 325 |
| AppSummary: | | IHC, WB |
| SpeciesSummary: | | Hu, Mu, Rt |
| ALTnames: | | # Medium tumour antigen associated 61kDa protein antibody # MGC786 antibody # PP2A alpha antibody # PP2A PR65 alpha isoform antibody # PP2Aalpha antibody # PP2Ac antibody # PP2CA antibody # PPP2CA antibody # Protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform antibody # Protein phosphatase 2 catalytic subunit alpha isoform antibody # Protein phosphatase 2 regulatory subunit A alpha isoform antibody # Replication protein C antibody # RP C antibody # RPC antibody # Serine threonine protein phosphatase 65 kDa antibody # Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform antibody |
| PackageSize: | | 0.1 ml |
| GeneralRef: | | 1. Janssens, V. and J. Goris. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353: 417-439 (2001). 2. Zabrocki, P., et al. Protein phosphatase 2A on track for nutrient-induced signalling in yeast. Mol. Microbiol. 43: 835-842 (2002). 3. Milward, T.A., et al. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem. Sci. 24: 186-191 (1999). 4. Chen, J., et al. Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. Science 257: 1261-1264 (1992). |
| more information: | | company product webpage |
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