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| Catalog Code: | NB110-57430 |
| Product Name: | PP2A Antibody |
| Product Description: | Rabbit Monoclonal anti-PP2A (Y119) |
| Clone: | Y119 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | A synthetic peptide corresponding to residues near C-terminus of human PP2A |
| Specificity: | A synthetic peptide corresponding to residues near C-terminus of human PP2A was used as immunogen. This antibody detects both alpha and beta isoforms of PP2A. |
| Cross Reactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml protein A purified Rabbit ascites. |
| Uses: | WB: 1:5,000-10,000IHC: 1; 250-500ICC: 1:50IP: 1:100 |
| Background: | Protein phosphatase type 2A (PP2A) is a protein serine/threonine phosphatase that controls fundamental cellular processes, including transcription, translation, metabolism, cell growth, apoptosis, and varied other signal transduction pathways (1-3). PP2A is comprised of a core enzyme, which is made up of catalytic C and regulatory A (PR65) subunits, and a secondary regulatory B subunit. This B subunit contains four different protein families. In response to EGF or insulin, it has been shown that Src phosphorylates PP2A at Tyr307, thereby inactivating PP2A (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunohistochemistry , immunoprecipitation , Western Blot , Immunocytochemistry |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-PP2A A antibody, anti-PP2A alpha antibody, anti-PP2A B antibody, anti-PP2A beta antibody, anti-PP2Ac antibody, anti-PP2C alpha antibody, anti-PP2C beta antibody, anti-PP2CA antibody, anti-PP2CB antibody, anti-PPP2CA antibody, anti-PPP2CB antibody, anti-Protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform antibody, anti-Protein phosphatase 2 (formerly 2A) catalytic subunit beta isoform antibody, anti-Protein phosphatase 2 antibody, anti-Protein phosphatase 2 catalytic subunit alpha isoform antibody, anti-Protein phosphatase 2 catalytic subunit beta isoform antibody, anti-Protein Phosphatase 2A antibody, anti-Protein phosphatase type 2A catalytic subunit antibody, anti-Replication protein C antibody, anti-RP C antibody, anti-Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform antibody, anti-Serine/threonine protein phosphatase 2A catalytic subunit beta isoform antibody, anti-Serine/threonine protein phosphatase antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Janssens, V. and J. Goris. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353: 417-439 (2001). 2. Zabrocki, P., et al. Protein phosphatase 2A on track for nutrient-induced signalling in yeast. Mol. Microbiol. 43: 835-842 (2002). 3. Milward, T.A., et al. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem. Sci. 24: 186-191 (1999). 4. Chen, J., et al. Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. Science 257: 1261-1264 (1992). |
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