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| Catalog Code: | NB110-57429 |
| Product Name: | PP1 beta Antibody |
| Product Description: | Rabbit Monoclonal anti-PP1 beta (EP1804Y) |
| Clone: | EP1804Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues on human PP1 beta was used as an immunogen. |
| Cross Reactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:100,000-200,000IHC: 1:100-250FC: 1:25IP: 1:100 |
| Background: | Protein phosphatase 1 (PP1) is a major eukaryotic protein serine/threonine phosphatase that regulates an enormous variety of cellular functions through the interaction of its catalytic subunit (PP1c) with over fifty different established or putative regulatory subunits (1). The coordinated and reciprocal action of serine/threonine (Ser/Thr) protein kinases and phosphatases produces transient phosphorylation, a fundamental regulatory mechanism for many biological processes. PP1 is ubiquitously distributed and regulates a broad range of cellular functions, including glycogen metabolism, cell-cycle progression and muscle relaxation. PP1 has evolved effective catalytic machinery but lacks substrate specificity. Substrate specificity is conferred upon PP1 through interactions with a large number of regulatory subunits (2). It has been shown that PP1 determines the efficacy of learning and memory by limiting acquisition and favoring memory decline. When PP1 is genetically inhibited during learning, short intervals between training episodes are sufficient for optimal performance (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis, immunohistochemistry, immunoprecipitation, Western Blot |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-MGC3672 antibody, anti-PP 1B antibody, anti-PPP1CB antibody, anti-PPP1CD antibody, anti-Protein phosphatase 1 beta antibody, anti-Protein phosphatase 1 catalytic subunit beta isoform antibody, anti-Protein phosphatase 1 delta antibody, anti-Serine threonine protein phosphatase PP1 beta catalytic subunit antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Cohen PT, J Cell Sci 115(Pt2):241-56, 2002. 2. Terrak M, et al. Nature 429(6993):780-4, 2004. 3. Genoux D, et al. Nature 418(6901):929-30, 2002. |
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