| CatalogCode: | NB110-57423 |
| ProductName: | Phospho PLC-Beta 3 (pS1105) Antibody |
| Product Description: | Rabbit Monoclonal anti-Phospho PLC-Beta 3 (pS1105) (EPR1498Y) [Ser1105] |
| Clone: | EPR1498Y |
| Clonality: | Monoclonal |
| Specificity: | A phosphor-specific peptide corresponding to residues surrounding Serine 1105 of human PLC-â3 was used as an immunogen. This antibody detects PLC- â3 phosphorylated on Ser1105. |
| CrossReactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:2000 |
| Background: | PLC beta 3 plays an important role in initiating receptor-mediated signal transduction. Activation of PLC takes place in many cells as a response to stimulation by hormones, growth factors, neurotransmitters, and other ligands (1). PLCB3 plays an important role in signal transduction and, moreover, shows loss of expression in some endocrine tumors, in accordance with a putative tumor suppressor gene function (2). Morphine and other micro opioids regulate a number of intracellular signaling pathways, including the one mediated by phospholipase C (PLC). Data demonstrate that PLC beta3 constitutes a significant pathway involved in negative modulation of mu opioid responses, perhaps via protein kinase C, and suggests the possibility that differences in opioid sensitivity among individuals could be, in part, because of genetic factors (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| ALTnames: | # 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase beta 3 antibody # Phosphoinositide phospholipase C antibody # Phospholipase C beta 3 antibody # Phospholipase C beta 3 (phosphatidylinositol specific) antibody # PLC beta 3 antibody # PLCB3 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Lagercrantz J, et al. Genomics 26(3):467-72, 1995. 2. Weber G, et al. Hum Genet 99(1):130-2, 1997. 3. Xie W, et al. Proc Natl Acad Sci, 96(18): 10385-90, 1999. |
| Phosphorylated: | Ser1105 |
|