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| Catalog Code: | NB110-57379 |
| Product Name: | LIG4 Antibody |
| Product Description: | Rabbit Polyclonal anti-LIG4 |
| Clonality: | Polyclonal |
| ListPrice: | 315 |
| Gene ID: | 3981 |
| Concentration: | 1 mg/ml |
| Immunogen: | Synthetic peptide derived from a region between residues 275 - 324 of human DNA Ligase IV. |
| Cross Reactivity: | Human. Oter species not tested. |
| Packaging: | 0.1 mg protein A purified Rabbit antisera. |
| Uses: | Western Blot: dilute in 5% skim milk, PBS buffer. |
| Background: | LIG4 encodes a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | protein A purified |
| Host Name: | Rabbit |
| Buffer: | PBS with 2% sucrose. |
| Application Summary: | ELISA 1:312,500, Western Blot 1:800, Immunohistochemistry-Paraffin 1:125-1:250, |
| Species Summary: | Hu, |
| Alternate Names: | anti-DNA ligase IV ATP dependent antibody, anti-DNA joinase antibody, anti-DNA ligase 4 antibody, anti-DNA repair enzyme antibody, anti-LIG 4 antibody, anti-LIG4 antibody, anti-Ligase IV antibody, anti-Ligase IV DNA ATP dependent antibody, anti-Polydeoxyribonucleotide synthase [ATP] 4 antibody, anti-Polydeoxyribonucleotide synthase 4 antibody, anti-Polydeoxyribonucleotide synthase antibody, anti-Polynucleotide ligase antibody, anti-Sealase antibody |
| Package Size: | 0.1 mg |
| Preservative: | No preservatives |
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more information: | company product webpage |