| CatalogCode: | | NB110-57362 |
| ProductName: | | PKC theta Antibody |
| Product Description: | | Rabbit Monoclonal anti-PKC theta (EPR1488Y) |
| Clone: | | EPR1488Y |
| Clonality: | | Monoclonal |
| Specificity: | | A synthetic peptide corresponding to residues surrounding Tyrosine 538 of human PKC theta was used as an immunogen. This antibody detects both phosphorylated (pT538) and unphosphorylated PKC theta. |
| CrossReactivity: | | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | | 0.1 ml |
| Uses: | | WB: 1:500 |
| Background: | | Members of the protein kinase C (PKC) family of serine/threonine kinases play a key role in regulating the differentiation and growth of diverse cell types and, to date, the cloning of seven mammalian PKC genes encoding eight distinct isoforms has been reported. PKC theta represents an additional member of the PKC family, and its predominant expression in hematopoietic cells suggests that it may play a role in signal transduction and growth regulatory pathways unique to these cells (1). PKC theta is a Ca(2+)-independent PKC isoform that is selectively expressed in T lymphocytes (and muscle), and is thought to play an important role in T cell receptor-induced activation (2). Among the several PKC isoenzymes expressed in T cells, PKC theta is unique in being rapidly recruited to the site of TCR clustering. It has been shown that PKC theta is essential for TCR-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development (3). |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | | 325 |
| AppSummary: | | WB |
| SpeciesSummary: | | Hu, Mu, Rt |
| ALTnames: | | # MGC126514 antibody # MGC141919 antibody # nPKC theta antibody # nPKCtheta antibody # OTTHUMP00000043364 antibody # OTTHUMP00000043365 antibody # PKC 0 antibody # PKC0 antibody # PRKCQ antibody # PRKCT antibody # Protein kinase C theta antibody # Protein kinase C theta type antibody # Protein Kinase Ctheta antibody |
| PackageSize: | | 0.1 ml |
| GeneralRef: | | 1. Baier G, et al. J Biol Chem 268(7):4997-5004, 1993 2. Witte S, et al. J Biol Chem 275(3):1902-9, 2000 3. Sun Z, et al. Nature 404(6776):402-7, 2000 |
| more information: | | company product webpage |
|