| CatalogCode: | NB110-57359 |
| ProductName: | PKC delta Antibody |
| Product Description: | Rabbit Monoclonal anti-PKC delta (EP1484Y) |
| Clone: | EP1484Y |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues near the C-terminus of human PKC delta was used as an immunogen. |
| CrossReactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:500IHC: 1:50ICC: 1:50 - 100FC: 1:15 |
| Background: | PKC-delta has a biological activity which is closely related to Pkc1, and PKC-delta activates the Pkc1-mediated pathway through an activation of the Bck1 kinase. PKC-delta appears to play a critical role in growth control of yeast and mammalian cells. Suppression experiments suggest that PKC-delta desensitizes the pathway by regulating an aspect of G protein function (1). PKC-delta phosphorylates hRad9 in vitro and in cells exposed to genotoxic agents. It has been shown that PKC-delta is required for binding of hRad9 to Bcl-2. In concert with these results, inhibition of PKC-delta attenuates Rad9-mediated apoptosis. These findings demonstrate that PKC-delta is responsible for the regulation of Rad9 in the Hus1-Rad1 complex and in the apoptotic response to DNA damage (2). It has been reported a mechanism for the regulation of peripheral B-cell survival by serine/threonine protein kinase Cdelta (PKC-delta): spontaneous death of resting B cells is regulated by nuclear localization of PKC-delta that contributes to phosphorylation of histone H2B at serine 14 (S14-H2B) (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, IHC, WB, ICC |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| ALTnames: | # D14Ertd420e antibody # MAY 1 antibody # MAY1 antibody # MGC49908 antibody # nPKC delta antibody # PCKd antibody # PKC d antibody # PKC delta antibody # PKCD antibody # PKCdelta antibody # PRKC D antibody # PRKC delta antibody # PRKCd antibody # Protein Kinase C delta antibody # Protein kinase C delta type antibody # Protein Kinase Cdelta antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Nomoto S, et al. Genes Cells 2(10):601-14, 1997 2. Yoshida K, et al. EMBO J 22(6):1431-41, 2003 3. Mecklenbrauker I, et al. Nature 431(7007), 2004 |
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