| CatalogCode: | NB110-57347 |
| ProductName: | PI3-Kinase p110 subunit beta Antibody |
| Product Description: | Rabbit Monoclonal anti-PI3-Kinase p110 subunit beta (Y384) |
| Clone: | Y384 |
| Clonality: | Monoclonal |
| Immunogen: | A synthetic peptide of human PI3-K p110 beta. |
| Specificity: | A synthetic peptide of human PI3-K p110 beta was used as an immunogen. |
| CrossReactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:500Flow Cytometry: 1:40IP: 1:50 |
| Background: | PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. PI3-K consists of two subunits; p85 and p10. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K (1-2). Four isoforms of p110 has been found; á, â, ã, and the Ä subunit. The beta isoform forms heterodimers with p85 subunit (3). p110-beta has a role in regulating the formation and stability of integrin adhesion bonds (alpha-2B and beta-3), which are necessary for shear force-induced platelet activation (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, IP, WB |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| ALTnames: | anti-DKFZp779K1237 antibody, anti-MGC133043 antibody, anti-p110 BETA antibody, anti-Phosphatidylinositol 3 kinase catalytic beta polypeptide antibody, anti-Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit beta isoform antibody, anti-Phosphoinositide 3 kinase catalytic beta polypeptide antibody, anti-PI3 kinase p110 subunit beta antibody, anti-PI3K antibody, anti-PI3K beta antibody, anti-PI3Kbeta antibody, anti-PI3KCB antibody, anti-PIK3C1 antibody, anti-PtdIns 3 kinase p110 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Otsu, M., Hiles, I. D., Gout, I., Fry, M. J., Ruiz-Larrea, F., Panayatou, G., Thompson, A., Dhand, R., Hsuan, J., Totty, N., Smith, A. D., Morgan, S. J., Courtnidge, S. A., Parker, P. J., and Waterfield, M. D. (1992) Cell 65, 91-104 2. Hiles, I. D., Otsu, M., Volinia, S., Fry, M. J., Gout, I., Dhand, R., Panayatou, G., Ruiz-Larrea, F., Thompson, A., Totty, N. F., Hsuan, J. J., Courtnidge, S. A., Parker, P. J., and Waterfield, M. D. (1991) Cell 70, 419-429 3. Hu, P., Mondino, A., Skolnik, E. Y., and Schlessinger, J. (1993) Mol. Cell. Biol. 13, 7677-7688 4. Jackson et al. Nature Med. 11: 507-514, 2005. |
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