| CatalogCode: | NB110-57346 |
| ProductName: | P13-Kinase p110 subunit alpha Antibody |
| Product Description: | Rabbit Monoclonal anti-P13-Kinase p110 subunit alpha (EP383Y) |
| Clone: | EP383Y |
| Clonality: | Monoclonal |
| Immunogen: | Synthetic peptide of human near the C-terminal of P13-K p110 alpha. |
| Specificity: | A synthetic peptide of human near the C-term of PI3-K p110 alpha was used as an immunogen. |
| CrossReactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml Tissue culture supernatant Rabbit ascites. |
| Uses: | WB: 1:1,000-5,000ICC: 1: 100-250IP: 1: 30 |
| Background: | PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. PI3-K consists of two subunits; p85 and p10. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K (1-2). Four isoforms of p110 has been found; á, â, ã, and the Ä subunit. The alpha isoform, also known as PI3KCA, is a transforming oncogene (3) that was shown to have activating mutations in nine types of cancers such as colon, brain, breast and stomach (4-5). Three hot spot mutations (E542K and E545K; and H1047R) make p110á a potential drug target. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IP, WB, ICC |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| ALTnames: | anti-caPI3K antibody, anti-MGC142161 antibody, anti-MGC142163 antibody, anti-p110 alpha antibody, anti-p110alpha antibody, anti-Phosphatidylinositol 3 kinase catalytic alpha polypeptide antibody, anti-Phosphatidylinositol 3 kinase catalytic 110 KD alpha antibody, anti-Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform antibody, anti-Phosphatidylinositol 45 bisphosphate 3 kinase catalytic subunit alpha isoform antibody, anti-Phosphoinositide 3 kinase catalytic alpha polypeptide antibody, anti-PI3 kinase p110 subunit alpha antibody, anti-PI3K antibody, anti-PI3KC A antibody, anti-PIK3C A antibody, anti-PIK3CA antibody, anti-PtdIns 3 kinase p110 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Otsu et al. (1992) Cell 65, 91-104 2. Hiles et al. (1991) Cell 70, 419-429 3. Chang HW, Aoki M, Fruman D, et al. Science 1997;276:1848-50. 4. Depowski PL, Rosenthal SI, Ross JS. Mod Pathol 2001;14:672-6 5. Bose S, Crane A, Hibshoosh H, Mansukhani M, Sandweis L, Parsons R, Hum Pathol 2002;33:405-9. |
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