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| Catalog Code: | NB110-57319 |
| Product Name: | Parkin Antibody |
| Product Description: | Rabbit Monoclonal anti-Parkin (EP668y) |
| Clone: | EP668y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues in human Parkin was used as immunogen. |
| Cross Reactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:500IHC: 1:50-100ICC: 1:100-250Flow cytometry: 1:80 |
| Background: | Parkin is a RING-type E3 ubiquitin-protein ligase which binds to E2 ubiquitin-conjugating enzymes. Parkin is composed of a ubiquitin-like domain at its amino terminus and two RING finger motifs flanking a cysteine-rich region that is known as the in between RING fingers (IBR) motif (1-2). Involved in the ubiquitination pathway for misfolded proteins derived from endoplasmic reticulum, Parkin contributes to protection from neurotoxicity induced by unfolded protein stresses. Parkin can also ubiquitinates itself to promotes its own degradation (3).Defective Parkin is involved in Parkinson's diseases and in autosomal recessive juvenile Parkinsonism (AR-JP) (4-5) |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis, immunohistochemistry, Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-AR JP antibody, anti-FRA6E antibody, anti-LPRS 2 antibody, anti-LPRS2 antibody, anti-PARK 2 antibody, anti-PARK2 antibody, anti-Parkinson disease (autosomal recessive juvenile) 2 antibody, anti-Parkinson disease protein 2 antibody, anti-Parkinson juvenile disease protein 2 antibody, anti-PDJ antibody, anti-PRKN antibody, Ubiquitin E3 ligase PRKN antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Morett, E. and Bork, P., 1999. Trends Biochem. Sci. 24, pp. 229-231. 2. Kitada, T.; Asakawa, S.; Minoshima, S.; Mizuno, Y.; Shimizu, N. : Mammalian Genome 11: 417-421, 2000. 3. Imai, Y.; Soda, M.; Hatakeyama, S.; Akagi, T.; Hashikawa, T.; Nakayama, K.; Takahashi, R. :Molec. Cell 10: 55-67, 2002. 4. Imai, Y., Soda, M. and Takahashi, R., 2000. J. Biol. Chem. 275, pp. 35661-35664. 5. Zhang, Y., Gao, J., Chung, K.K., Huang, H., Dawson, V.L. and Dawson, T.M., 2000. Natl. Acad. Sci. USA 97, pp. 13354-13359. |
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