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| Catalog Code: | NB110-57317 |
| Product Name: | PAK1 Phosphospecific Antibody |
| Product Description: | Rabbit Monoclonal anti-Phospho PAK1 (pS20) (EP655Y) [Ser20] |
| Clone: | EP655Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Synthetic phosphopeptide corresponding to residues surrounding Serine 20 of human PAK1. |
| Specificity: | A phosphor-specific peptide corresponding to residues surrounding Serine 20 on human PAK1 was used as an immunogen. This antibody recognized PAK1 phosphorylated at Ser20. |
| Cross Reactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml Tissue culture supernatant Rabbit ascites. |
| Uses: | WB: 1:2000IP: 1:50 |
| Background: | p21-activated kinase 1 (PAK1) is a member of a family of serine/threonine protein kinase defined by their interaction with the small GTPases, Cdc42 and Rac (1-2). The PAK proteins can be essentially divided into two categories, group I (PAK1, PAK2 and PAK3) and group II (PAK4, PAK5 and PAK6), based on their structures (3). PAK1 participates in regulating the actin cytoskeleton, focal adhesion contacts, cell motility, apoptosis and transcription. It also promotes the disassembly of stress fibers (4-5). PAK1 also binds PIX (PAK-binding protein), COOL and adapter protein Nck (5). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunoprecipitation , Western Blot |
| Species Summary: | Hu, Mu(-), Rt(-), |
| Alternate Names: | anti-Alpha PAK antibody, anti-Alpha PAK antibody, anti-p21 activated kinase 1 antibody, anti-p21 activated kinase1 antibody, anti-p21/Cdc42/Rac1 activated kinase 1 antibody, anti-p65 PAK antibody, anti-PAK 1 antibody, anti-PAK alpha antibody, anti-Serine/threonine protein kinase PAK 1 antibody, anti-Serine/threonine protein kinase anti-PAK1 antibody, anti-STE20 homolog (yeast) antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| Phosphorylated: | Ser20 |
| General References: | 1. Manser E, et al. Nature 363:364-367, 1994. 2. Daniels RH, et al. Trends Biochem. Sci. 24:350-355, 1999 3. Jaffer ZM, et al. Int. J. Biochem. Cell Biol 34:713-717, 2002 4. Sanders LC, et al. Science 283: 2083-2085, 1999. 5. Sells MA, et al. J. Cell Biol. 145, pp. 837-849, 1999. |
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