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| Catalog Code: | NB110-57309 |
| Product Name: | p63 (p73L) Antibody |
| Product Description: | Rabbit Monoclonal anti-p63 (p73L) (Y289) |
| Clone: | Y289 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues to the C-term of human p63 (p73L) was used as immunogen. This antibody should detect both isoforms 2,9,10,11 and 12. |
| Cross Reactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 10,000-20,000ICC: 1:250-500IP: 1:50 |
| Background: | p63 (also called KET, p51, p40, AIS, and p73L) (1) is a transcription factor that shares a significant amino acid identity with p53 and p73. p63 and p73 can both activate p53-responsive genes and induce apoptosis upon over- expression (2). p63 has an additional coding region in the C-termini (not found in p53) that can undergo complex alternative splicing giving rise to 3 splice forms (á, â, and ã) (3). Additionally, two isoforms can be found; one containing the N-terminal transactivating domain (TA) or the (ÄN) lacking TA (2). p63 plays a more fundamental role associated with development and differentiation. Mutations in p63, although not as common as p53, may result in the ADULT, AEC and ECC3 syndrome (4-5). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunoprecipitation, Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu(-), Rt(-), |
| Alternate Names: | anti-AIS antibody, anti-B(p51A) antibody, anti-B(p51B) antibody, anti-Chronic ulcerative stomatitis protein antibody, anti-CUSP antibody, anti-EEC3 antibody, anti-Keratinocyte transcription factor KET antibody, anti-KET antibody, anti-LMS antibody, anti-OFC8 antibody, anti-p40 antibody, anti-p51 antibody, anti-p53 like transcription factor antibody, anti-p53 related protein antibody, anti-p63 antibody, anti-P73 antibody, anti-p73H antibody, anti-p73L antibody, anti-RHS antibody, anti-SHFM4 antibody, anti-TP63 antibody, anti-TP73 antibody, anti-TP73L antibody, anti-tumor protein 63 kDa with strong homology to p53 antibody, anti-tumor protein p63 antibody, anti-Tumor protein p73 antibody, anti-tumor protein p73-like antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Schmale, H., and Bamberger, C. (1997) Oncogene 15, 1363-1367 2. Yang, A., Kaghad, M., Wang, Y., Gillett, E., Fleming, M. D., Dotsch, V., Andrews, N. C., Caput, D., and McKeon, F. (1998) Mol. Cell 2, 305-316 3. Levrero, M., De Laurenzi, V., Costanzo, A., Gong, J., Melino, G., and Wang, J. Y. (1999) Cell Death Differ. 6, 1146-1153 4. Amiel J., Bougeard G., Francannet C., Raclin V., Munnich A., Lyonnet S., Frebourg T.; Eur. J. Hum. Genet. 9:642-645(2001).1 5. Akahoshi K., Sakazume S., Kosaki K., Ohashi H., Fukushima Y.; Am. J. Med. Genet. 120:370-373(2003). |
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