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| Catalog Code: | NB110-57301 |
| Product Name: | p53 Antibody |
| Product Description: | Rabbit Monoclonal anti-p53 (E26) |
| Clone: | E26 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues following the transcription activation domain of human p53 was used as immunogen. The antibody should recognize human wild-type and mutant p53. |
| Cross Reactivity: | Reacts in human and rat. Does not react in mouse. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:1,000IHC: 1:100ICC: 1:50-100 |
| Background: | p53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair (1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers (3). p53 is frequently mutated or inactivated in about 60% of cancers (4,5). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.05% BSA. |
| Application Summary: | immunohistochemistry, Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu(-), Rt, |
| Alternate Names: | Antigen NY-CO-13 antibody Cellular tumor antigen p53 antibody Cys 51 Stop antibody HGNC11998 antibody LFS1 antibody p53 Cellular Tumor Antigen antibody p53 Tumor Suppressor antibody Phosphoprotein p53 antibody TP53 antibody Transformation related protein 53 antibody TRP53 antibody Tumour Protein p53 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Levine, A.J. p53, the cellular gatekeeper for growth and division. Cell 88: 323-331 (1997). 2. Lakin, N.D. and S.P. Jackson. Regulation of p53 in response to DNA damage. Oncogene 18: 7644-7655 (1999). 3. Vogelstein, B. Cancer. A deadly inheritance. Nature 348: 681-2(1990). 4. Hoolstein, M., et al. p53 mutations in human cancers. Science 253: 49-53(1991). 5. Harris C.C. p53: at the crossroads of molecular carcinogenesis and risk assessment. Science 262: 1980-1981(1993). |
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