| CatalogCode: | NB110-57286 |
| ProductName: | Phospho-p120 Catenin (Y228) Antibody |
| Product Description: | Rabbit Monoclonal anti-Phospho-p120 Catenin (Y228) (E205) [Tyr228] |
| Clone: | E205 |
| Clonality: | Monoclonal |
| Specificity: | A synthetic phospho-peptide corresponding to residues surrounding Tyr228 of human p120 Catenin was used as immunogen. The antibody only detects p120 Catenin phosphorylated on Tyrosine 228. . |
| CrossReactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1: 5,000 - 20,000IHC: 1:50ICC: 1:100IP: 1:100 |
| Background: | Catenins are proteins that are linked to the cytoplasmic domain of transmembrane cadherins. p120 Catenin is one member of this Armadillo gene family of junctional plaque proteins (1-3). The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be important for cadherins cell-adhesion properties. Recently it became clear that some catenins also mediate nuclear signaling (1). p120 Catenin is implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, IP, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | Cadherin associated Src substrate antibody CAS antibody Catenin (cadherin associated protein) delta 1 antibody Catenin delta 1 antibody CTNND 1 antibody CTNND antibody CTNND1 antibody KIAA0384 antibody p120 antibody P120 CAS antibody p120 catenin antibody P120 CTN antibody p120(cas) antibody p120(ctn) antibody P120CAS antibody P120CTN antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Keirsebilck, A., et al. Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms. Genomics 50: 129-46 (1998). 2. Aho, S., et al. Specific sequences in p120ctn determine subcellular distribution of its multiple isoforms involved in cellular adhesion of normal and malignant epithelial cells. J Cell Sci. 115: 1391-402 (2002). 3. van Hengel, J., et al. Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression. Proc Natl Acad Sci U S A. 96: 7980-5 (1999). |
| Phosphorylated: | Tyr228 |
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