| CatalogCode: | | NB110-57285 |
| ProductName: | | p120 Catenin Antibody |
| Product Description: | | Rabbit Monoclonal anti-p120 Catenin (YE372) |
| Clone: | | YE372 |
| Clonality: | | Monoclonal |
| Specificity: | | A synthetic peptide corresponding to residues near N-terminus (before aa101) of human p120 Catenin (isoform 1ABC, 968AA) was used as immunogen. This antibody also detects splice isoform 1, 1A, 1B, 1C, 1AB, 1AC, 1BC, 2, 2A, 2B, 2C, 2AB, 2AC, 2BC, and 2ABC of p120 Catenin. |
| CrossReactivity: | | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | | 0.1 ml |
| Uses: | | WB: 1:1,000-5,000IHC: 1:100-250ICC: 1:250Flow Cytometry: 1:50IP: 1:80 |
| Background: | | Catenins are proteins that are linked to the cytoplasmic domain of transmembrane cadherins. p120 Catenin is one member of this Armadillo gene family of junctional plaque proteins (1-3). The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be important for cadherins cell-adhesion properties. Recently it became clear that some catenins also mediate nuclear signaling (1). p120 Catenin is implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | | 325 |
| AppSummary: | | FACS, IHC, IP, WB, ICC |
| SpeciesSummary: | | Hu, Mu(-), Rt(-) |
| PackageSize: | | 0.1 ml |
| GeneralRef: | | 1. Keirsebilck, A., et al. Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms. Genomics 50: 129-46 (1998). 2. Aho, S., et al. Specific sequences in p120ctn determine subcellular distribution of its multiple isoforms involved in cellular adhesion of normal and malignant epithelial cells. J Cell Sci. 115: 1391-402 (2002). 3. van Hengel, J., et al. Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression. Proc Natl Acad Sci U S A. 96: 7980-5 (1999). |
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