| CatalogCode: | NB110-57272 |
| ProductName: | NBS1 Antibody |
| Product Description: | Rabbit Monoclonal anti-NBS1 (Y1121) |
| Clone: | Y1121 |
| Clonality: | Monoclonal |
| Immunogen: | Synthetic peptide corresponding to residues near C terminus of human p95 NBS1. |
| Specificity: | A synthetic peptide corresponding to residues near C-terminus of human Nibrin was used as immunogen. |
| CrossReactivity: | Reacts in human and mouse. Does not react in rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Background: | Nibrin (also known as NBS1 or p95) contains 2 modules found in cell cycle check point; a forkhead-associated domain & a BRCA1 C-teminal repeat (1). In mammalian cells, Nibrin forms a complex with Mre11 & Rad50 (MRN). Nuclear localization of the MRN complex is relevant for chromosomal stability, meiotic recombination, DNA repair & telomere maintenance in eukaryotic cells(2-4). Mutation in Nibrin & Mre11 causes respectively two related disorders, Nijmegen breakage syndrome (NBS) & Ataxia-Telangiectasia- like disorder (ATLD). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, IP, WB, ICC |
| SpeciesSummary: | Hu, Mu, Rt(-) |
| ALTnames: | anti-AT V1 antibody AT V2 antibody, anti-ATV antibody, anti-Cell cycle regulatory protein p95 antibody, anti-FLJ10155 antibody, anti-MGC87362 antibody, anti-NBN antibody, anti-NBS 1 antibody, anti-NBS antibody, anti-NBS1 antibody, anti-Nibrin antibody, anti-Nijmegen breakage syndrome antibody, anti-Nijmegen breakage syndrome protein 1 antibody, anti-p95 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Trujillo, K. M., Yuan, S. S., Lee, E. Y., and Sung, P. (1998) J. Biol. Chem. 273, 21447-21450 2. Dolganov, G. M., Maser, R. S., Novikov, A., Tosto, L., Chong, S., Bressan, D. A., and Petrini, J. H. (1996) Mol. Cell. Biol. 16, 4832-4841 3. Zhu, J., Petersen, S., Tessarollo, L. & Nussenzweig, A. (2001) Curr. Biol. 11, 105-109 4. Varon, R., Vissinga, C., Platzer, M., Cerosaletti, K. M., Chrzanowska, K. H., Saar, K., Beckmann, G., Seemanova, E., Cooper, P. R., Nowak, N. J., et al. (1998) Cell 93, 467-476. |
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