| CatalogCode: | NB110-57238 |
| ProductName: | Phospho SEK/MEKK4 (Ser 80) Antibody |
| Product Description: | Rabbit Monoclonal anti-Phospho SEK/MEKK4 (Ser 80) (EP1075Y) |
| Clone: | EP1075Y |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues near the N-term of human MKK4 was used as immunogen. |
| CrossReactivity: | Reacts in human and mouse. Does not react in rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:5000IHC: 1:50 - 100IP: 1:50 |
| Background: | MKK4, also known as JNKK1 and SEK1, is a dual specificity kinase that belongs to the Ser/Thr protein kinase family. MKK4 is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MKK4 phosphorylate and activate p38 MAP kinase and JNK but not ERK 1/2 (1-2). JNK is activated by dual phosphorylation at Thr and Tyr by MKK4 and MKK7; although MKK4 will preferentially phosphorylate Tyr (3). MKK4 is also known to be a tumor suppressor, as mutations inactivating the MKK4 gene have been found in 5% of a wide variety of tumor types (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | IHC, IP, WB |
| SpeciesSummary: | Hu, Mu, Rt(-) |
| ALTnames: | c Jun N terminal kinase kinase 1 antibody Dual specificity mitogen activated protein kinase kinase 4 antibody JNK Activated Kinase 1 antibody JNK activating kinase 1 antibody JNKK1 antibody MAP kinase kinase 4 antibody MAPK ERK kinase 4 antibody MAPKK4 antibody MEK4 antibody PRKMK4 antibody SAPK ERK kinase 1 antibody SEK1 antibody SERK1 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Lin, et al. Science 268: 286-290, 1995 2. Sanchez I, , et al Nature (Lond) 1994;372:794-8 3. Lawler, et al. Curr. Biol. 8, 1387-1390, 1998 4. Yoshida et al. Cancer Res. 59, 5483-5487, 1999 |