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| Catalog Code: | NB110-57235 |
| Product Name: | Musashi1 Antibody |
| Product Description: | Rabbit Monoclonal anti-Musashi1 (EP1302) |
| Clone: | EP1302 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Synthetic peptide corresponding to residues on the N terminal of human Musashi 1 / Msi1. |
| Specificity: | A synthetic peptide corresponding to residues on the N-terminus of human Musashi1 was used as an immunogen. |
| Cross Reactivity: | Reacts in human and rat. Does not react in mouse. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:2000IHC: 1:50 - 100ICC: 1:250 - 500FC: 1:40IP: 1:50 |
| Background: | Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Recently, expression of Musashi1 has been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in oncogenic development. Results suggest that Musashi1 expression may be an important factor in the development of several types of carcinoma such as human hepatoma, and may be a useful molecular marker for tumor detection. (1). Recent findings demonstrate that translational regulation contributes to cell-fate specification. The evolutionarily conserved, neural RNA-binding protein Musashi1 controls neural cell fate. The protein functions in maintenance of the stem-cell state, differentiation, and tumorigenesis by repressing translation of particular mRNAs. In mammals it might play an important role in activating Notch signaling by repressing translation of the Notch inhibitor m-Numb (2). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis , immunohistochemistry , immunoprecipitation , Western Blot , Immunocytochemistry |
| Species Summary: | Hu, Mu(-), Rt, |
| Alternate Names: | anti-Msi 1 antibody, anti-Msi1 antibody, anti-Musashi homolog 1 antibody, anti-Musashi1 antibody, anti-RNA binding protein Musashi homolog 1 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Shu HJ, et al. Biochem Biophys Res Commun 293(1):150- 4, 2002. 2. Okana H, et al. J Cell Sci. 115(7):1355-9, 2002. |
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