| CatalogCode: | NB110-57234 |
| ProductName: | MUC1 isoform 7 Antibody |
| Product Description: | Rabbit Monoclonal anti-MUC1 isoform 7 (EP1024Y) |
| Clone: | EP1024Y |
| Clonality: | Monoclonal |
| Immunogen: | Synthetic peptide corresponding to residues near the N-terminus of human MUC1 |
| Specificity: | A synthetic peptide corresponding to residues near the N-terminus of human MUC1 was used as an immunogen. |
| CrossReactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | WB: 1:1000IHC: 1:100 - 250FC: 1:30IP: 1:50 |
| Background: | Mucins are high molecular weight glycoproteins that provide a protective layer on epithelial surfaces and are involved in cell-cell interactions, signaling, and metastasis. MUC1 consists of an extracellular subunit and a membrane-associated subunit (1). The two moieties are produced from a single precursor polypeptide by an early proteolytic cleavage event but remain associated throughout intracellular processing and transport to the cell surface. It has been shown that MUC1 expression inhibits erbB1 (regulators of cell survival and growth) degradation and also E-cadherin (2). Isoform 7 of MUC1 behaves as a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, IHC, IP, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-Breast carcinoma associated antigen DF3 antibody, anti-CA 15 3 antibody, anti-Carcinoma associated mucin antibody, anti-CD 227 antibody, anti-CD227 antibody, anti-CD227 antigen antibody, anti-DF3 antigen antibody, anti-EMA antibody, anti-Episialin antibody, anti-Epithelial basement membrane antigen antibody, anti-Epithelial membrane antigen antibody, anti-Epithelial mucin tandem repeat sequence antibody, anti-H23 antigen antibody, anti-H23AG antibody, anti-HGNC:7508 antibody, anti-MAM6 antibody, anti-MUC 1 antibody, anti-Mucin 1 antibody, anti-Mucin 1 precursor antibody, anti-Mucin 1 transmembrane antibody, anti-Mucin1 antibody, anti-Peanut reactive urinary mucin antibody, anti-PEM antibody, anti-PEMT antibody, anti-Polymorphic epithelial mucin antibody, anti-PUM antibody, anti-Tumor associated epithelial membrane antigen antibody, anti-Tumor associated mucin antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Parry S, et al, Biochem Biophys Res Commun 283(3): 715-20, 2001 2. Pochampalli MR et al., Oncogene, Sept 18, 2006 3. Kigure S, et al. Rinsho Byori 54(5): 447-52, 2006 |
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