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| Catalog Code: | NB110-57225 |
| Product Name: | Moesin Antibody |
| Product Description: | Rabbit Monoclonal anti-Moesin (EP1863Y) |
| Clone: | EP1863Y |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Specificity: | A synthetic peptide corresponding to residues near the C-terminus of human Moesin was used as an immunogen. |
| Cross Reactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:100,000IHC: 1:100 - 250ICC: 1:100 - 250FC: 1:25IP: 1:70 |
| Background: | Moesin (membrane-organizing extension spike protein) has previously been characterized as a possible receptor protein for heparan sulfate and also as a cytoskeletal linker protein that stabilizes cell surface microvilli, filopodia and lamellipodia. Data indicate that moesin is identical to the 77-kDa band that copurifies with ezrin in its isolation from human placenta (1). Members of the ezrin-radixin-moesin (ERM) family of membrane-cytoskeletal linking proteins have NH2- and COOH-terminal domains that associate with the plasma membrane and the actin cytoskeleton, respectively (2). It has been demonstrated that ezrin-radixin-moesin proteins are rapidly inactivated after antigen recognition through a Vav1-Rac1 pathway. The resulting disanchoring of the cortical actin cytoskeleton from the plasma membrane decreased cellular rigidity, leading to more efficient T cell-antigen-presenting cell conjugate formation (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis, immunohistochemistry, immunoprecipitation, Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-Membrane organizing extension spike protein antibody, anti-Moesin/anaplastic lymphoma kinase fusion protein antibody, anti-MSN antibody, anti-MSN/ALK fusion antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Lankes WT, et al. Proc Natl Acad 88(19):8297-301, 1991 2. Reczek D, et al. J Cell Biol 139(1):169-79, 1997 3. Faure S, et al. Nat Immunol 5(3):272-9, 2004 |
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