| request information: |
|
| Catalog Code: | NB110-57221 |
| Product Name: | MMP-3 Antibody |
| Product Description: | Rabbit Monoclonal anti-MMP-3 (EP1186Y) |
| Clone: | EP1186Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Synthetic peptide corresponding to residues near the C-terminus of human MMP3. |
| Specificity: | A synthetic peptide corresponding to residues near the C-terminus of human MMP-3 was used as an immunogen. |
| Cross Reactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml Tissue culture supernatant Rabbit ascites. |
| Uses: | WB: 1:1000IHC: 1:100 - 250ICC: 1:100 - 250 |
| Background: | Effective inhibitors of matrix metalloproteinases (MMPs), a family of connective tissue-degrading enzymes, could be useful for the treatment of diseases such as cancer, multiple sclerosis, and arthritis (1). Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. MMP3 (stromelysin) is a secreted metalloprotease with a wide range of substrate specificities. MMP3 is synthesized in a preproenzyme form with a calculated size of 54 kDa and a 17-amino acid long signal peptide. Data indicate that the expression and the possible involvement of secreted metalloproteases in tumorigenesis result from a specific interaction between the transforming factor and the target cell, which may vary in different species (2). In neural studies, matrix metalloproteinase-3 (MMP-3) was newly induced and activated in stressed dopamine cells, and the active form of MMP-3 (actMMP-3) was released into the medium. The released actMMP-3, as well as catalytically active recombinant MMP-3 (cMMP-3) led to microglial activation and superoxide generation in microglia and enhanced DA cell death. (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunohistochemistry , Western Blot , Immunocytochemistry |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-Matrix metalloproteinase 3 antibody, anti-Matrix metalloproteinase 3 preproprotein antibody, anti-MGC126102 antibody, anti-MGC126103 antibody, anti-MGC126104 antibody, anti-MMP 3 antibody, anti-Progelatinase antibody, anti-SL 1 antibody, anti-SL1 antibody, anti-STMY antibody, anti-STMY1 antibody, anti-STR1 antibody, anti-Stromelisin 1 antibody, anti-Stromelysin 1 progelatinase antibody, anti-Transin 1 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Wilhelm SM, et al. Proc Natl Acad Sci USA 84(19):6725-9, 1987. 2. Pavlovsky AG, et al. Protein Sci, 8(7):1455-62, 1999. 3. Kim YS, et al. FASEB J 21(1):179-87, 2007. |
order or
more information: | company product webpage |
|