| request information: |
|
| Catalog Code: | NB110-57220 |
| Product Name: | MMP-21 Antibody |
| Product Description: | Rabbit Monoclonal anti-MMP-21 (EP1277Y) |
| Clone: | EP1277Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide that corresponds to residues on human MMP-21 were used as an immunogen. This antibody recognizes 2 isoforms of MMP-21. |
| Cross Reactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:200,000IHC: 1:100 - 250ICC: 1:50 - 100FC: 1:40IP: 1:30 |
| Background: | Matrix metalloproteinases (MMPs) play key roles in tissue remodelling under normal development and, especially, in diseases ranging from malignancies to stroke. Expression of MMP-21 is controlled uniquely by Pax and Notch transcription factors known to be critical for organogenesis. MMP-21 is expressed transiently in mouse embryogenesis and increased in embryonic neuronal tissues. Observations indicate that there is an important specific function for MMP-21 in embryogenesis, especially in neuronal cells (1). MMP-21 is expressed in various human fetal and adult tissues as well as in cancer cell lines. MMP-21 protein can also be detected in malignancies such as ovarian and colon carcinomas by immunohistochemical staining. Findings suggest that MMP-21 functions in embryogenesis and tumor progression (2). Results suggest that during development, MMP-21 expression is temporally and spatially tightly controlled. Unlike many classical MMPs, it is present in various normal adult tissues. Among epithelial MMPs, MMP-21 has a unique expression pattern in cancer (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis, immunohistochemistry, immunoprecipitation, Western Blot, Immunocytochemistry |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-Matrix metalloproteinase 21 antibody, anti-MIFR antibody, anti-MMP 21 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Marchenko GN, et al. Biochem 372(Pt2):503-15, 2003 2. Ahokas K, et al. Gene 301(1-2):31-41, 2002. 3. Ahokas K, et al. Lab Invest 83(12):1887-99, 2003. |
order or
more information: | company product webpage |
|