| CatalogCode: | NB110-57203 |
| ProductName: | MKK3 (N-term) Antibody |
| Product Description: | Rabbit Monoclonal anti-MKK3 (N-term) (EP555Y) |
| Clone: | EP555Y |
| Clonality: | Monoclonal |
| Specificity: | A synthetic peptide corresponding to residues in the N-terminus of human MKK3 was used as immunogen. |
| CrossReactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:5,000-20,000Flow Cytometry: 1:20IP: 1:50 |
| Background: | Mitogen-acitvated protein kinase kinase 3 (MKK3) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MAPKs require dual phosphorylation on threonine and tyrosine residues, an activation step carried out by MAPK kinase (1-2). MKK3, closely related to MKK6, efficiently phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines and environmental stress but not JNK or ERK (3). MKK3 is activated by mitogenic and environ-mental stress stimulus as well as by insulin. MKK3 is necessary for the expression of glucose transporter and participates in the MAP kinase- mediated signaling cascade (4). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 325 |
| AppSummary: | FACS, IP, WB |
| SpeciesSummary: | Hu, Mu(-), Rt(-) |
| ALTnames: | Dual specificity mitogen activated protein kinase kinase 3 antibody MAP kinase kinase 3 antibody MAPK ERK kinase 3 antibody MAPKK 3 antibody MAPKK3 antibody MEK 3 antibody MKK3 antibody mMKK3b antibody PRKMK3 antibody Protein kinase mitogen activated kinase 3 antibody SKK2 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Han, J.; Lee, J.-D.; Jiang, Y.; Li, Z.; Feng, L.; Ulevitch, R. J. : J. Biol. Chem. 271: 2886-2891, 1996. 2. Seger, R.; Krebs, E. G. : FASEB J. 9: 726-735, 1995. 3. Bernd Stein, Helen Brady, Maria X. Yang , David B. Young, Miguel S. Barbosa, Volume 271, Number 19, Issue of May 10, 1996 pp. 11427-11433 4. Fujishiro et al. J. Biol. Chem., Vol. 276, Issue 23, 19800-19806, 2001 |
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