| CatalogCode: | | NB110-57200 |
| ProductName: | | Met (N-term) Antibody |
| Product Description: | | Rabbit Monoclonal anti-Met (N-term) (EP1454Y) |
| Clone: | | EP1454Y |
| Clonality: | | Monoclonal |
| Specificity: | | A synthetic peptide corresponding to residues near the N-terminus of human Met was used as an immunogen. |
| CrossReactivity: | | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | | 0.1 ml |
| Uses: | | WB: 1:2000IHC: 1:100 - 250ICC: 1:100 - 250 |
| Background: | | Met is a receptor protein-tyrosine kinase (RPTK) for hepatocyte growth factor (HGF), which is a multifunctional cytokine controlling cell growth, morphogenesis, and motility. Met overexpression has been identified in a variety of human cancers (1). Met kinase domain possesses unique features that distinguish met from other members of the src family of protein tyrosine kinases. These results also demonstrate that the product of the activated met gene is a fusion protein and that the amino terminal end of this fusion protein exhibits homology to laminin B1 (2). Data suggest that RanBP9, functioning as an adaptor protein for the Met tyrosine kinase domain, can augment the HGF-Met signaling pathway and that RanBP9 overexpression may cause constitutive activation of the Ras signaling pathway (1). Hereditary papillary renal carcinoma (HPRC) is a recently recognized form of inherited kidney cancer Results suggest that missense mutations located in the MET proto-oncogene lead to constitutive activation of the Met protein and papillary renal carcinomas (3) |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | | 325 |
| AppSummary: | | IHC, WB, ICC |
| SpeciesSummary: | | Hu, Mu(-), Rt(-) |
| ALTnames: | | c met antibody cmet antibody Hepatocyte growth factor receptor Precursor antibody HGF receptor antibody HGF SF receptor antibody HGF/SF receptor antibody HGFR antibody Met proto oncogene tyrosine kinase antibody Oncogene MET antibody RCCP2 antibody Renal cell carcinoma papillary 2 gene antibody SF receptor antibody |
| PackageSize: | | 0.1 ml |
| GeneralRef: | | 1. Wang D, et al. J Biol Chem 277(39):36216-22, 2002. 2. Chan AM, et al. Oncogene 1(2):229-33, 1987. 3. Schmidt L, et al. Nat Genet. 16(1):68-73, 1997. |
| more information: | | company product webpage |
|