| CatalogCode: | | NB110-57197 |
| ProductName: | | MEKK4 Antibody |
| Product Description: | | Rabbit Monoclonal anti-MEKK4 (EP551Y) |
| Clone: | | EP551Y |
| Clonality: | | Monoclonal |
| Specificity: | | A synthetic peptide corresponding to residues in human MEKK4 was used as immunogen. This antibody is predicted to detect splice isoform 2 based on sequence analysis. |
| CrossReactivity: | | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | | 0.1 ml |
| Uses: | | WB: 1:1,000-5,000IHC: 1:50-100ICC: 1:100-250Flow Cytometry: 1:20 |
| Background: | | MEK kinase 4 (MEKK4), also known as MTK1, is a Ser/Thr protein kinase belonging to the MAP kinase kinase kinase family (1). This protein contains a protein kinase catalytic domain at the C-terminus. The N-terminal, non-kinase domain may contain a regulatory domain. MEKK4 regulates p38 and JNK, butnot ERK pathway, through the phosphorylation of the MAP2Ks MKK3 and MKK6 and MKK4 and MKK7 respectively (1-2). |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | | 325 |
| AppSummary: | | FACS, IHC, WB, ICC |
| SpeciesSummary: | | Hu, Mu(-), Rt(-) |
| PackageSize: | | 0.1 ml |
| GeneralRef: | | 1. Takekawa, M.F. Posas, and H. Saito. 1997 EMBO J. 16:4973-4982 2. Gerwins, P., J.L. Blank, and G.L. Johnson. 1997. J. Biol. Chem. 272:8288-8295 |
| more information: | | company product webpage |
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