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| Catalog Code: | NB110-57181 |
| Product Name: | MAPKAP Kinase-2 Antibody |
| Product Description: | Rabbit Monoclonal anti-MAPKAP Kinase-2 (E341) |
| Clone: | E341 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues near C-terminus of human MAPKKAP Kinase-2 was used as immunogen. |
| Cross Reactivity: | Reacts in human, mouse, and rat. Not tested in other species. |
| Packaging: | 0.1 ml |
| Uses: | WB: 1:500-1,000IP: 1:200 |
| Background: | MAPKAP Kinase-2 is part of mitogen-activated protein (MAP) kinase family which includes MAP kinase kinase kinase (1) and MAP kinase kinase (2). Once activated MAP Kinase-2 will in turn regulate the phosphorylation and activation of many substrates including cell surface molecules, cytoskeletal proteins, transcription factors, and protein kinases (3). MAPKAP Kinase-2 is also known to be a MAP kinase substrate (p38 MAPK ) (4) in addition to phosphorylating low molecular weight heat shock proteins (Hsp27 in humans) and tyrosine hydroxylase. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunoprecipitation, Western Blot |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-MAP Kinase Activated Protein Kinase 2 antibody, anti-MAPK activated protein kinase 2 antibody, anti-MAPKAP kinase 2 antibody, anti-MAPKAPK 2 antibody, anti-MAPKAPK2 antibody, anti-Mitogen Activated Protein Kinase Activated Protein Kinase 2 antibody, anti-MK 2 antibody, anti-MK2 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Kyriakis, J. M., App, H., Zhang, X. F., Banerjee, P., Brautigan, D. L., Rapp, U. R., and Avruch, J. (1992) Nature 358, 417-421 2. Ahn, N. G., Seger, R., and Krebs, E. G. (1992) Curr. Opin. Cell Biol. 4, 992-999 3. Davis, R. J. (1993) J. Biol. Chem. 268, 14553-14556 4. Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Liamazares, A., Zamannillo, D., Hunt, T., and Nebreda, A. R. (1994) Cell 78, 1027-1037 |
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