| CatalogCode: | | NB110-57178 |
| ProductName: | | MALT1/MLT1 (N-term) Antibody |
| Product Description: | | Rabbit Monoclonal anti-MALT1/MLT1 (N-term) (EP603Y) |
| Clone: | | EP603Y |
| Clonality: | | Monoclonal |
| Specificity: | | A synthetic peptide corresponding to residues in the N-term of human MALT1 was used as immunogen. This antibody is predicted to detect splice isoform 2 based on sequence analysis. |
| CrossReactivity: | | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | | 0.1 ml |
| Uses: | | WB: 1:2,000Flow Cytometry: 1:30IP: 1:50 |
| Background: | | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), also known as MLT1 or paracaspase 1, is a member of the human paracaspase family and an interacting partner of B-cell lymphoma 10 (Bcl-10) (1). In vitro, In vitro, MALT1 synergizes with BCL10 to enhance nuclear factor B activation (2) and to mediate IB kinase (IKK) activation by facilitating the ubiquitinylation of the NF-B essential modulator (NEMO) (3). MALT1 is found in recurrent chromosomal translocations in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT). One common translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in up-regulation of Bcl-10 and MALT1 (4). Another common translocation creates a fusion between MALT1 and the inhibitor of apoptosis gene API2 (cIAP2/HIAP1) (5). |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | | 325 |
| AppSummary: | | FACS, IP, WB |
| SpeciesSummary: | | Hu, Mu(-), Rt(-) |
| ALTnames: | | caspase-like protein antibody DKFZp434L132 antibody MALT 1 antibody MALT associated translocation antibody MALT lymphoma associated translocation antibody MLT 1 antibody MLT antibody MLT1 antibody Mucosa associated lymphoid tissue lymphoma translocation gene 1 antibody Mucosa associated lymphoid tissue lymphoma translocation protein 1 antibody Paracaspase antibody |
| PackageSize: | | 0.1 ml |
| GeneralRef: | | 1. Uren AG, O'Rourke K, Aravind LA, et al. Mol Cell. 2000;6: 961-967 2. Lucas PC, Yonezumi M, Inohara N, et al. J Biol Chem. 2001;276: 19012-19019. 3. Zhou H, Wertz I, O'Rourke K, et al. Nature. 2004;427: 167-171. 4. Dierlamm et al.; Blood 1999, 93:3601-3609 5. Akagi et al. Oncogene 1999, 18:5785-5794 |
| more information: | | company product webpage |
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