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| Catalog Code: | NB110-57171 |
| Product Name: | c-Myb Antibody |
| Product Description: | Rabbit Monoclonal anti-c-Myb (EP769Y) |
| Clone: | EP769Y |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Synthetic peptide corresponding to residues near the N-terminus of human c-Myb. |
| Specificity: | A synthetic peptide corresponding to residues near the N-terminus of human c-myb was used as an immunogen. |
| Cross Reactivity: | Reacts in human. Does not react in mouse or rat. Not tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Background: | The c-Myb proto-oncogene is a 75 kDa protein involved in growth regulation and differentiation in many different cell types but it is predominantly expressed in immature hemopoietic cells where it plays an important role in cell proliferation. c-Myb activity is directly regulated by cyclin D1 and CDKs and it is believed that c-Myb activity is regulated during the cell cycle in hematopoietic cells (2). Disrupting c-myb function might, therefore, prove an effective therapeutic strategy for controlling leukemic cell growth (3). c-Myb binds to promoter sequences of genes such as c-Myc or Bcl-2 that are expressed in cutaneous T-cell lymphoma. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunohistochemistry 1:100 - 250, immunoprecipitation 1:50, Western Blot 1:10,000, Immunocytochemistry 1:100 - 250, |
| Species Summary: | Hu, Mu(-), Rt(-), |
| Alternate Names: | anti-Avian myeloblastosis viral (v Myb) oncogene homolog antibody, anti-c-myb CDS antibody, anti-Cmyb antibody, anti-Efg antibody, anti-Myb antibody, anti-Myb protein antibody, anti-Myb proto oncogene protein antibody, anti-Myeloblastosis oncogene antibody, anti-v Myb antibody, anti-v myb avian myeloblastosis viral oncogene homolog antibody, anti-v Myb myeloblastosis viral oncogene homolog (avian) antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Kalkbrenner F, et al. Oncogene(5):657-61, 1990 2. Lei W, et al. Blood(10):3855-61, 2005 3. Ratajczak MZ, et al Proc Natl Acad Sci(24):11823-7, 1992 |
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